PSL’s CakeStand Tray Dryer is a vacuum drying oven with an innovative hanging shelf design providing enhanced drying for high grade, temperature and oxygen sensitive products.
Powder Systems Limited (PSL) launched a few years ago this new tray dryer design to overcome inherent difficulties of traditional vacuum ovens such as poor heat uniformity, difficult cleaning for pharmaceutical grade and GMP requirements and challenging scalability and ergonomics.
The CakeStand Tray Dryer allows capacities from kilograms to large-scale production thanks to a modular design and provides technology scale-up from R&D and process development to commercial manufacturing of APIs, HPAPIs and other pharmaceutical compounds.
Typically static drying is required to eliminate residual moisture content from hygroscopic substances and is found at the end of the upstream process line following reaction and filtration.
Static drying under vacuum has been used in pharmaceutical manufacturing for decades but PSL developed a ground-breaking design providing both high quality and performance. The wet substances contained in trays are in direct contact with the heated shelves where heating fluid uniformly circulates. The walls can also be heated and provide an optimum vacuum drying process for enhanced drying time and homogeneous dried finished product. To prove such heat uniformity across all heating plates, PSL engineers performed temperature mapping tests on a 12 shelf CakeStand Tray Dryer showing a maximum recorded temperature variation of +/- 1.0°C between the shelves. Nitrogen can also be injected into the wet product during the drying process when necessary thanks to an advanced pipework design within the chamber.
The innovative hanging shelf design also contributes to the enhanced drying allowing the heat to flow within the chamber. But most importantly, the hanging shelves design provides a high quality cleaning process with CIP system that can achieve 2.5ppm to non-detectable result. PSL renowned quality can also been seen throughout the solid construction of the pressure rated heating shelves and the vacuum cabinet. For compact design requirements, the CakeStand Tray Dryer can be supplied with a pivot door greatly reducing the footprint of the equipment. Along with an optimum tray size, the pivot door design ensures less opportunity for overreaching or accidental spillage.
As an original pioneer of high containment solutions, PSL can integrate the CakeStand Tray Dryer within a dedicated glovebox or multi-purpose isolator achieving proven nano-containment for highly potent, cytotoxic, antibody drug conjugates and oncological products. The CakeStand Tray Dryer design itself also avoids any hidden pockets or non-accessible gaps which can make the cleaning procedure problematic.
The PSL range of CakeStand Tray Dryers starts from bench top compact solutions for process development, up to 12 shelves free standing units for large scale vacuum drying. Available standard construction materials available are 316L stainless steel and Alloy C22 (ASME and U-Stamp possible) and design temperatures range from 0° to 150°C. Instrumentation such as temperature probe or pressure or full control are available along with TCU and vacuum pump packages to meet any requirements.
With installations in USA, Japan and across Europe, the CakeStand Tray Dryer is becoming a reference in the pharmaceutical industry for optimum drying process. PSL has been supporting the pharmaceutical, biopharmaceutical, chemical and laboratory industries since 1989 with advanced filtration, drying and nano-containment solutions. www.powdersystems.com